Natasha caplan nih

Many cellular peptides, and likely nearly all viral peptides, derive from rapidly degraded proteins, which consist of defective ribosomal products DRiPs and short-lived proteins SLiPs. I will describe the nature of a number of influenza virus DRiPs and how ribosome profiling facilitates the identification of peptides derived from non-canonically translated cellular DRiPs.

I will also discuss how cells with ribosomes lacking individual protein subunits demonstrate either enhanced or decreased peptide generation in a subunit-specific manner and how this can be exploited by cancer cells to escape immunosurveillance. I will present a model to explain how peptide generation avoids the law of mass action to generate a highly diverse peptide repertoire immunopeptidome that enables pathogen and tumor recognition.

This talk will illustrate how, in over 4 decades of research, cell biology, virology, and immunology can be combined to dissect a medically important immune effector mechanism. View Organizer Website. Content Responsible: Alice Sollazzo alice. October 22, , — Add to calendar. Organizer Spotlight Seminar Series events scilifelab.

October 22 — CEST.

Kathryn zoon

Spotlight Seminar Series. Google Calendar. Last updated: Content Responsible: Alice Sollazzo alice. Necessary Necessary. Functional Functional.